Yueyang Jia source Biological Technology Co., Ltd.

name：  Doxorubicin hydrochloride

CAS: 25316-40-9

Melting point 216 ° C (dec.) (Lit.)

Specific rotation D20 + 248 ± 2 ° (c = 0.1 in methanol)

Storage conditions 2-8 ° C

Solubility H2O: 10 mg / mL, clear, red-orange

Color orange to dark red

Soluble in water.

Maximum wavelength (λmax) 497nm (H2O) (lit.)

Merck 14,3439

InChIKey MWWSFMDVAYGXBV-RUELKSSGSA-N

Chemical nature of orange needle-shaped crystals, melting point 204-205 ℃. Soluble in water and alcohol, insoluble in acetone, benzene, chloroform, ether.

Adriamycin is an antitumor antibiotic that inhibits the synthesis of RNA and DNA, strongest inhibitory effect on RNA, anti-tumor spectrum is broader, have a role in a variety of tumors, is a cycle of non-specific drugs, a variety of The growth cycle of tumor cells have a killing effect

Use antitumor antibiotics, doxorubicin effect in the heart of mitochondrial DNA. Reverse transcriptase and RNA polymerase inhibitors, immunosuppressive agents; can be inserted into the DNA chain. Clinically, cancer chemotherapy, mainly for acute and chronic leukemia, malignant lymphoma.

Uses Doxorubicin is an antibiotic anti-tumor drug that penetrates into cells and cross-links with tumor cells DNA, inhibits DNA replication, and blocks the action of RNA polymerase and inhibits the synthesis of RNA; its cytotoxicity is related to free radicals Formation and tumor cell membrane binding and breaking fast cell membrane; widely used in cell culture or rat kidney disease, myocardial ischemia and other aspects of modeling materials; for the inhibition of macromolecular biosynthesis

Use for the treatment of acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin's disease and non-Hodgkin's lymphoma, breast cancer, lung cancer, ovarian cancer

Production methods from the light gray strain of Streptomyces (Str. Peucetius var. Caesius) culture medium derived. The chemical structure of this product is similar to daunorubicin, so it can be obtained by chemical conversion of daunorubicin. It has been chemically synthesized.